What are the applications of external coil tube heating stainless steel reaction kettle in the pharm
The outer coil tube heating stainless steel reactor (referred to as "outer coil tube reactor") is widely used in the pharmaceutical industry for processes that require correct temperature control, clean environment, and chemical reaction/mixing operations due to its characteristics of uniform heating, correct temperature control, clean material (stainless steel corrosion-resistant), and compact st
The outer coil tube heating stainless steel reactor (referred to as "outer coil tube reactor") is widely used in the pharmaceutical industry for processes that require correct temperature control, clean environment, and chemical reaction/mixing operations due to its characteristics of uniform heating, correct temperature control, clean material (stainless steel corrosion-resistant), and compact structure. The specific application scenarios are as follows:
1. Synthesis reaction of active pharmaceutical ingredients
Chemical synthesis process: In the synthesis reaction of raw materials such as antibiotics, vitamins, etc., the outer coil is heated by circulating thermal oil, steam, or hot water to provide a stable heat source for the reaction, and the uniformity of heating can reduce side reactions caused by local overheating, ensuring the purity of the product.
Temperature sensitive reaction: Suitable for steps that require correct control of reaction temperature (such as reflux, constant temperature reaction), such as esterification, acylation, oxidation, etc. The indirect heating method of the outer coil can avoid direct contact with the material by open flames or electric heating rods, reducing the risk of pollution.
2. Extraction and concentration of traditional Chinese medicine
Chinese medicine extraction: in the production of Chinese medicine decoction pieces and traditional Chinese patent medicines and simple preparations, it is used for water extraction, alcohol extraction and other extraction processes. The external coil heating can evenly raise the temperature, promote the dissolution of effective ingredients of medicinal materials (such as alkaloids, flavonoids), and avoid local high temperature damage to heat sensitive ingredients (such as volatile oil).
Concentration operation: Low temperature concentration is performed on the extracted medicinal solution (by controlling the temperature of the outer coil to achieve reduced pressure concentration), reducing the loss of effective ingredients, especially suitable for heat sensitive traditional Chinese medicine extracts (such as ginsenosides and polysaccharides).
3. Mixing and dissolution in formulation production
Drug preparation: In the preparation process of oral liquid, injection solution, paste and other preparations, it is used to dissolve solid excipients (such as excipients, stabilizers) or mix multiple liquid raw materials. Heating with an outer coil can accelerate the dissolution/mixing process, and stainless steel material (such as 316L) is corrosion-resistant and easy to clean, meeting GMP requirements for equipment cleanliness (to avoid drug contamination).
Emulsification and Suspension: For cream like formulations (such as ointments and creams) that require heating to promote emulsification, uniform heating of the outer coil can ensure the stability of the emulsification system and avoid delamination.
4. Preparation of medicinal excipients
Synthesis and processing of excipients: In the preparation of medicinal excipients (such as dextrin, magnesium stearate, coating materials), it is used for heating dissolution, stirring mixing, or reaction synthesis. For example, the dissolution of coating materials (such as hydroxypropyl methylcellulose) requires correct temperature control, and external coil heating can meet its process requirements.
Pre treatment before drying: Some auxiliary materials need to be heated and mixed in a reaction kettle before entering the drying process. The heating function of the outer coil can be combined with stirring to evenly preheat the materials and improve subsequent drying efficiency.
5. Production of sterile preparations
Aseptic reaction and sterilization assistance: In the production of sterile preparations such as injections and freeze-dried powder injections, the outer coil reaction kettle can be used in conjunction with sterilization processes (such as sterilization of materials or equipment surfaces through high-temperature steam heating), and the stainless steel material is easy to clean and disinfect (in accordance with CIP/SIP cleaning standards), avoiding microbial contamination.
6. Laboratory and pilot research and development
Small and pilot stages: In the small and pilot stages of new drug development, pharmaceutical research and development institutions use small external coil reaction kettles to simulate production processes and test the effects of reaction temperature and time on products. Their temperature control and cleanliness characteristics ensure the reliability of experimental data and provide parameter basis for large-scale production.
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